Research Findings

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Paldus B, Lee MH, Jones HM, McAuley SA, Horsburgh JC, Roem KL, Ward GM, MacIsaac RJ, Cohen N, Colman PG, Jenkins AJ, O’Neal DN. Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study. Diabetes Technol Ther. 2019 Jan;21(1):56-58. doi: 10.1089/dia.2018.0279. PubMed PMID: 30620641.

Burckhardt MA, Chetty T, Smith GJ, Adolfsson P, de Bock M, Jones TW, Davis EA. Use of Continuous Glucose Monitoring Trends to Facilitate Exercise in Children with Type 1 Diabetes. Diabetes Technol Ther. 2019 Jan;21(1):51-55. doi: 10.1089/dia.2018.0292. PubMed PMID: 30620642.

Slykerman RF, Joglekar MV, Hardikar AA, Satoor SN, Thompson JMD, Jenkins A, Mitchell EA, Murphy R. Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age. Gene. 2019 Apr 30;694:97-101. doi: 10.1016/j.gene.2019.01.017. Epub 2019 Feb 7. PubMed PMID: 30738962.

Farr RJ, Wong WKM, Maynard CL, Tersey SA, Mirmira RG, Hardikar AA, Joglekar MV. Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA. J Biol Methods. 2019;6(2). doi: 10.14440/jbm.2019.280. Epub 2019 Jun 3. PubMed PMID: 31328130; PubMed Central PMCID: PMC6641562.

Clements MA, Schwandt A, Donaghue KC, Miller K, Lück U, Couper JJ, Foster N, Schröder C, Phelan H, Maahs D, Prinz N, Craig ME; Australasian Diabetes Data Network (ADDN) Study Group, the T1D Exchange Clinic Network (T1DX), and the German/Austrian/Luxembourgian Diabetes-Patienten-Verlaufsdokumentation (DPV) initiative. Five heterogeneous HbA1c trajectories from childhood to adulthood in youth with type 1 diabetes from three different continents: A group-based modeling approach. Pediatr Diabetes. 2019 Aug 16. doi: 10.1111/pedi.12907

Poddar A, Joglekar MV, Hardikar AA, Shukla R. A Novel Gene Delivery Approach Using Metal Organic Frameworks in Human Islet-Derived Progenitor Cells. Methods Mol Biol. 2019;2029:81-91. doi: 10.1007/978-1-4939-9631-5_7. PubMed PMID: 31273735.

Maynard CL, Wong WKM, Hardikar AA, Joglekar MV. Droplet Digital PCR for Measuring Absolute Copies of Gene Transcripts in Human Islet-Derived Progenitor Cells. Methods Mol Biol. 2019;2029:37-48. doi: 10.1007/978-1-4939-9631-5_4. PubMed PMID: 31273732.

Evans M, Smart CEM, Paramalingam N, Smith GJ, Jones TW, King BR, Davis EA. Dietary protein affects both the dose and pattern of insulin delivery required to achieve postprandial euglycaemia in Type 1 diabetes: a randomized trial. Diabet Med. 2019 Apr;36(4):499-504. doi: 10.1111/dme.13875. Epub 2019 Feb 20. PubMed PMID: 30537305.

Kiburg KV, Ward GM, O’Neal DN, MacIsaac RJ. Lipid-lowering therapy use and achievement of cholesterol targets in an Australian diabetes clinic. Intern Med J. 2018 Feb;48(2):201-204. doi: 10.1111/imj.13691. PubMed PMID: 29415350.

Penington JS, Penno MAS, Ngui KM, Ajami NJ, Roth-Schulze AJ, Wilcox SA, Bandala-Sanchez E, Wentworth JM, Barry SC, Brown CY, Couper JJ, Petrosino JF, Papenfuss AT, Harrison LC. Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis. Sci Rep. 2018 Mar 12;8(1):4386. doi: 10.1038/s41598-018-22491-7. PubMed PMID: 29531234; PubMed Central PMCID: PMC5847573.

Shetty VB, Fournier PA, Davey RJ, Retterath AJ, Paramalingam N, Roby, HC, Davis EA, Jones TW. The time lag prior to the rise in glucose requirements to maintain stable glycaemia during moderate exercise in a fasted insulinaemic state is of short duration and unaffected by the level at which glycaemia is maintained in type 1 diabetes. Diabetic Medicine. 2018; June. DOI: 10.1111/dme.13771

Wood A, O’Neal D, Furler J, Ekinci EI. Continuous glucose monitoring: a review of the evidence, opportunities for future use and ongoing challenges. Intern Med J. 2018 May;48(5):499-508. doi: 10.1111/imj.13770. Review. PubMed PMID: 29464891.

Allen DW, Kim KW, Rawlinson WD, Craig ME. Maternal virus infections in pregnancy and type 1 diabetes in their offspring: Systematic review and meta-analysis of observational studies. Rev Med Virol. 2018 May;28(3):e1974. doi: 10.1002/rmv.1974. Epub 2018 Mar 22. Review. PubMed PMID: 29569297.

Wu M, Phelan H, Schwandt A, Foster Nc, Couper J, Steigleder-Schweiger C, et al. BMI Z-Score Trajectories in Youth with T1D—An International Comparison. Diabetes. 2018 Jul 1;67(Supplement 1):2065-P.

de Bock M, McAuley SA, Abraham MB, Smith G, Nicholas J, Ambler GR, Cameron FJ, Fairchild JM, King BR, Geelhoed EA, Davis EA, O’Neal DN, Jones TW. Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol. BMJ Open. 2018 Aug 13;8(8):e020275. doi: 10.1136/bmjopen-2017-020275. PubMed PMID: 30104309; PubMed Central PMCID: PMC6091910.

Wentworth JM, Bediaga NG, Penno MAS, Bandala-Sanchez E, Kanojia KN, Kouremenos KA, Couper JJ, Harrison LC. Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood. Metabolomics. 2018 Sep 25;14(10):130. doi: 10.1007/s11306-018-1434-9. PubMed PMID: 30830461.

Larsson CR, Januszewski AS, McGrath RT, Ludvigsson J, Keech AC, MacIsaac RJ, Ward GM, O’Neal DN, Fulcher GR, Jenkins AJ. Suboptimal behaviour and knowledge regarding overnight glycaemia in adults with type 1 diabetes is common. Intern Med J. 2018 Sep;48(9):1080-1086. doi: 10.1111/imj.13798. PubMed PMID: 29573166.

de Bock M, McAuley SA, Abraham MB, Smith G, Nicholas J, Ambler GR, Cameron FJ, Fairchild JM, King BR, Geelhoed EA, Davis EA, O’Neal DN, Jones TW. Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol. BMJ Open. 2018 Aug 13;8(8):e020275. doi: 10.1136/bmjopen-2017-020275. PubMed PMID: 30104309; PubMed Central PMCID: PMC6091910.

Joglekar MV, Wong WKM, Maynard CL, Umrani MR, Martin D, Loudovaris T, Thomas HE, Dalgaard LT, Hardikar AA. Expression of miR-206 in human islets and its role in glucokinase regulation. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E634-E637. doi: 10.1152/ajpendo.00152.2018. Epub 2018 Jul 10. PubMed PMID: 29989852.

Williams MD, Joglekar MV, Satoor SN, Wong W, Keramidaris E, Rixon A, O’Connell P, Hawthorne WJ, Mitchell GM, Hardikar AA. Epigenetic and Transcriptome Profiling Identifies a Population of Visceral Adipose-Derived Progenitor Cells with the Potential to Differentiate into an Endocrine Pancreatic Lineage. Cell Transplant. 2019 Jan;28(1):89-104. doi: 10.1177/0963689718808472. Epub 2018 Oct 30. PubMed PMID: 30376726; PubMed Central PMCID: PMC6322142.

Wong WKM, Sørensen AE, Joglekar MV, Hardikar AA, Dalgaard LT. Non-Coding RNA in Pancreas and β-Cell Development. Noncoding RNA. 2018 Dec 13;4(4). doi: 10.3390/ncrna4040041. Review. PubMed PMID: 30551650; PubMed Central PMCID: PMC6315983.

Chetty, Tarini, Heather Roby, Nirubasini Paramalingam, Julie Dart, Wayne Soon, Grant J. Smith, Vinutha B. Shetty, Paul A. Fournier, Tim Jones, And Elizabeth A. Davis. 2018. “Short Sprints during Exercise Reduce Exercise-Mediated Hypoglycaemia in Type 1 Diabetes in a Real-Life Setting.” Diabetes 67 (Supplement 1): 747-P.

Paldus B, Lee MH, O’Neal DN: Insulin pumps in general practice Australian Prescriber 2018, 41:186-90 Doi: 10.18773/austprescr.2018.056.

Melissa H. Lee, MBBS1,2*, Barbora Paldus, MBBS1*, Balasubramanium Krishnamurthy, PhD1,3, Sybil A. McAuley1,2 , Rajiv Shah4, Alicia J. Jenkins, MD1,5, and David N. O’Neal, MD, FRACP1 “The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System” Journal of Diabetes Science and Technology 1–7

Barbora Paldus, MBBS,1,2 Melissa H. Lee, MBBS,1,2 Hannah M. Jones, BN,1,2 Sybil A. McAuley, PhD,1,2 Jodie C. Horsburgh, BN,1,2 Kerryn L. Roem, BSc,1 Glenn M. Ward, PhD,1,2 Richard J. MacIsaac, PhD,1,2 Neale Cohen, MBBS,3 Peter G. Colman, MD,4 Alicia J. Jenkins, MD,1,2,5 and David N. O’Neal, MD1,2 ‘Glucose Control Using a Standard Versus and Enhanced Hybrid Closed Loop System: A Randomized Crossover Study”

Diabetes Care. 2017 May 25 doi: 10.2337/dc16-2508, Prevalence of Celiac Disease in 52,721 Youth with Type 1 Diabetes: international comparison across three continents. Maria E Craig. 2.ADDN – Med J Aust. 2017 Feb 20;206(3):121-125.

The Australasian Diabetes Data Network: first national audit of children and adolescents with type 1 diabetes. Phelan H. Med J Aust. 2017 Feb 20;206(3):121-125.

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. Penno MA, Couper JJ.

Nathan W Zammit, Shane Grey “Improved survival characteristics of an inflammatory suppressed allograft”

Reduction in Hypoglycemia With the Predictive Low-Glucose Management System: A Long-Term Randomized Controlled Trial in Adolescents With Type 1 Diabetes. Diabetes Care 2017. PLGM study group.

Kosobrodova E, Wan JG, Kondyurin A., Thorn P* and Bilek MMM* (2017) *joint senior author. Improved multi-protein micro-contact printing on plasma immersion ion implanted polystyrene. ACS Applied Materials and Interfaces. DOI: 10.1021/acsami.7b15545

Phillips JE, Couper JJ, Penno MA, Harrison LC. “Type 1 diabetes: a disease of developmental origins”. Pediatric diabetes. 2017 Sep 1;18(6):417-21.

Kent SC, Mannering SI, Michels AW, Babon AB (2017) Deciphering the pathogenesis of human type 1 diabetes (T1D) by interrogating T cells from the ‘scene of the crime. Current Diabetes Reports 17: 95 (DOI 10.1007/s11892-017-0915-y)

Pizzolla A, Nguyen THO, Sant S, Jaffar J, Loudovaris T, Mannering SI, Thomas PG, Westall GP, Kedzierska K, Wakim LM (2018) “Influenza-specific resident memory T cells in human lung are highly proliferative, polyfunctional and maintain diverse TCR profiles” Journal of Clinical Investigation (Jan 8. pii: 96957. doi: 10.1172/JCI96957)

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW & Thomas HE. (2017). “Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.” Diabetes 66(6): 1650-1660.

Mannering SI, So M, Elso CM, Kay TWH Shuffling peptides to create T-cell epitopes-does the immune system play cards? Immunology and Cell Biology

Long-Term Maintenance of Human Pluripotent Stem Cells on cRGDfK-Presenting Synthetic Surfaces. Lambshead JW, Meagher L, Goodwin J, Labonne T, Ng E, Elefanty A, Stanley E, O’Brien CM, Laslett AL.Sci Rep. 2018 Jan 15;8(1):701

Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development. Meganathan K, Lewis EMA, Gontarz P, Liu S, Stanley EG, Elefanty AG, Huettner JE, Zhang B, Kroll KL. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):

Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination. Lee JY, Kim MJ, Deliyanti D, Azari MF, Rossello F, Costin A, Ramm G, Stanley EG, Elefanty AG, Wilkinson-Berka JL, Petratos S. EBioMedicine. 2017 Nov;25:122-135

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Bellmaine SF, Ovchinnikov DA, Manallack DT, Cuddy CE, Elefanty AG, Stanley EG, Wolvetang EJ, Williams SJ, Pera M.Elife. 2017 Sep 8;6. pii: e24502. doi:

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling. Navarro-Montero O, Ayllon V, Lamolda M, López-Onieva L, Montes R, Bueno C, Ng E, Guerrero-Carreno X, Romero T, Romero-Moya D, Stanley E, Elefanty A, Ramos-Mejia V, Menendez P, Real PJ.Stem Cells. 2017 Nov;35(11):2253-2266.

Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Xiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH. Cell Stem Cell. 2017 Sep 7;21(3):383-398

Human haematopoietic stem cell development: from the embryo to the dish. Ivanovs A, Rybtsov S, Ng ES, Stanley EG, Elefanty AG, Medvinsky A. Development. 2017 Jul 1;144(13):2323-2337.

Umrani MR, Joglekar MV, Somerville Glover E, Wong W, Hardikar AA (2017) Connexins and microRNAs: Interlinked players in regulating islet function? Islets; 9(5):99-108.

Hakami NY, Ranjan AK, Hardikar AA, Dusting GJ, Peshavariya HM. (2017) Role of NADPH Oxidase-4 in Human Endothelial Progenitor Cells. Front Physiol.; 8:150. doi: 10.3389/fphys.2017.00150. eCollection 2017.

Abraham MB, Nicholas JA, Crone M, Ly TT, Davis EA, Jones TW. The Importance of the Hawthorne Effect on Psychological Outcomes Unveiled in a Randomized Controlled Trial of Diabetes Technology. Journal of diabetes science and technology. 2017:1932296817747293.

Abraham MB, Nicholas JA, Smith GJ, Fairchild JM, King BR, Ambler GR, et al. Reduction in Hypoglycemia With the Predictive Low-Glucose Management System: A Long-Term Randomized Controlled Trial in Adolescents With Type 1 Diabetes. Diabetes care. 2017. THis publication featured in the Editorial

Abraham MB, Heels K, Nicholas JA, Cole C, Gebert R, Klimek J, et al. Unexpected Management Behaviors in Adolescents With Type 1 Diabetes Using Sensor-Augmented Pump Therapy. Journal of diabetes science and technology. 2018:1932296817752188.

Abraham MB, Davey RJ, Cooper MN, Paramalingam N, O’Grady MJ, Ly TT, et al. Reproducibility of the plasma glucose response to moderate-intensity exercise in adolescents with Type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association. 2017; 34:1291-5.

Kordbacheh F, O’Meara CH, Coupland LA, Lelliott PM, Parish CR (2017) Extracellular histones induce erythrocyte fragility and anaemia. Blood 130: 2884-2888

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM. Receptor clustering as a mechanism to regulate GPVI signalling in platelets. J Thromb. Haemost. (2017) 15: 549-564

Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM and Hoy JF. Decreased levels of platelet derived soluble glycoprotein VI detected prior to first diagnosis of coronary artery disease in HIV positive patients. Platelets (2017) 28: 301-304.

Stack JR, Madigan A, Helbert L, Dunne E, Gardiner EE, Andrews RK, Finan R, Smyth EJ, Kenny D and McCarthy GM. Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis. PLoS One (2017) 12(11): e0188027.

Coupland L, Hindmarsh L, Gardiner EE and Parish CR. Tumor cell ECM degradation and activated platelet membranes. Cancer Metastasis Rev. (2017) 36: 215-224

Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M. (2017) Understanding and preventing type 1 diabetes though the unique working model of TrialNet .Diabetologia 60: 2139-2147

Ahmadi Z, Perdomo J, Wong R, Chong BH. (2017) Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX. Platelets Dec 29, 1-5

Coupland LA, Hindmarsh EJ, Gardiner EE, Parish CR (2017) The influence of platelet membranes on tumour cell behaviour. Cancer Metastasis Rev 36: 215-224

Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs” Dev Cell. 2017 Dec 18;43(6):659-672

Abraham, M.B., Nicholas, J.A., Ly, T.T., Roby, H.C., Paramalingam, N., Fairchild, J., King, B.R., Ambler, G.R., Cameron, F., Davis, E.A., Jones, T.W. 2016, ‘Safety and efficacy of the predictive low glucose management system in the prevention of hypoglycaemia: Protocol for randomised controlled home trial to evaluate the Suspend before low function’, BMJ Open, 6, 4, pp. 011589

Abraham, M.B., de Bock, M., Paramalingam, N., O’Grady, M., Ly, T., George, C., Roy, A., Spital, G., Karula, S., Heels, K., Gebert, R., Fairchild, J.M., King, B.R., Ambler, G.R., Cameron, F., Davis, E.A., Jones, T.W. 2016, ‘Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management System’, DIABETES TECHNOLOGY & THERAPEUTICS, 18, 7, pp. 8.

Abraham, M.B., Davey, R., O’Grady, M.J., Ly, T.T., Paramalingam, N., Fournier, P.A., Roy, A., Grosman, B., Kurtz, N., Fairchild, J.M., King, B.R., Ambler, G.R., Cameron, F., Jones, T.W., Davis, E.A. 2016, ‘Effectiveness of a Predictive Algorithm in the Prevention of Exercise-Induced Hypoglycemia in Type 1 Diabetes’, Diabetes Technology and Therapeutics, 18, 9, pp. 543-550

Abraham MB, Gallego P, Brownlee W, Smith G, Davis E, Jones T Reduced prevalence of impaired awareness of hypoglycemia in a population-based clinic sample of youth with Type 1 diabetes Pediatric Diabetes. 2016

Coates PT, Grey ST. Finding a new home of islet cell transplants. Transplantation. 2016. Jul;100(7):1398-9.

Coughlan MT et al. Deficiency in apoptosis inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis. 2016. Diabetes doi: 10.2337/db15-0864 [Epub]

Coughlan MT, Nguyen TV, Penfold SA, Higgins GC, Thallas-Bonke V, Tan SM, Van Bergen NJ, Sourris KC, Harcourt BE, Thorburn DR6, Trounce IA5, Cooper ME4, Forbes JM7.Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes. Clin Sci (London) 2016 May;130(9):711-20. doi:10.1042/CS20150838. Epub 2016 Feb 1

David Maahs, Bruce Buckingham, Jessica Castle, Ali Cinar, Edward Damiano, Eyal Dassau, J. Hans DeVries, Francis J. Doyle III, Steven C. Griffen, Ahmad Haidar, Lutz Heinemann, Roman Hovorka, Timothy Jones, Craig Kollman, Boris Kovatchev, Brian Levy, Revital Nimri, David O’Neal, Moshe Philip, Eric Renard, Steven J. Russell, Stuart Weinzimer, Howard Zisser and John Lum. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016; 39(7):1175-9.

Helen Clapin, Helen Phelan, Laurance Bruns Jr, Richard Sinnott, Peter Colman, Maria Craig, Tim Jones; Australasian Diabetes Data Network (ADDN) Study Group. Australasian Diabetes Data Network: Building a Collaborative Resource. 2016 J Diabetes Sci Technol

Holmes-Walker DJ, Kay TW. Lomg term effects of islet transplantation. Current Opinions in Organ Transplantation 2016 Oct;21(5):497-502

Hu M, Wang YM, Wang Y, Zhang GY, Zheng G, Yi S, O’Connell PJ, Harris DC, ALexander SI. Regulatory T cells in kidney disease and transplantation. Kidney Int. 2016 Sep;90(3):502-14 -14.

Jessica Phillips, Jennifer Couper, Megan Penno, Leonard Harrison, ENDIA Study Group. Type 1 diabetes: a disease of developmental origins. Pediatr Diabetes 2016; Aug 15

Joglekar, M., Januszewski, A., Jenkins, A., Hardikar, A. (2016). Circulating microRNA Biomarkers of Diabetic Retinopathy. Diabetes, 65(1), 22-24.

Joglekar, M., Trivedi, P., Kay, T., Hawthorne, W., O’Connell, P., Jenkins, A., Hardikar, A., Thomas, H. (2016). Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. Apoptosis, 21(4), 379-389

Kim, K., Ho, A., Alshabee-Akil, A., Hardikar, A., Kay, T., Rawlinson, W., Craig, M. (2016). Coxsackievirus B5 infection induces dysregulation of microRNAs predicted to target known type 1 diabetes risk genes in human pancreatic islets. Diabetes, 65(4), 996-1003.

Noonan JE, Ward GM, Sarossy M, Man RE, Nguyen TT, Jenkins AJ, Dusting GJ, Lamoureux EL. 2016. Retinal Neuronal and Vascular Function in Type 1 Diabetes Adults during Glycaemic Clamps. Clinical and Experimental Pharmacology and Physiology doi: 10.1111/1440-1681.12540 [Epub]

O’Connell Coates PT, Grey ST. Finding a new home of islet cell transplants. Transplantation. 2016 Jul;100(7):1398-9

O’Connell Holmes-Walker DJ, Gunton JE, Payk M, Donath S, Hawthorne WJ, Loudovaris T, Anderson P, Ward GM, Kay TWH, O’Connell PJ for the Australian Islet Transplant consortium. Islet transplantation provides superior glycemic control with less hypoglycemia compared to continuous subcutaneous insulin infusion (CSII or multiple daily insulin injections (MDI). Transplantation 2016, Aug 3. E-pub ahead of print

O’Connell Holmes-Walker DJ, Kay TW. Long term effects of islet transplantation. Current Opinions in Organ Transplantation 2016 Oct;21(5):497-502.

O’Connell Hu M, Wang YM, Wang Y, Zhang GY, Zheng G, Yi S, O’Connell PJ, Harris DC, Alexander SI. Regulatory T cells in kidney disease and transplantation. Kidney Int. 2016 Sep;90(3):502-14.

O’Connell Wu J, Hu M, Qian YW, Hawthorne WJ, Burns H, Liuwantara D, Alexander SI, Yi S, O’Connell PJ. In vivo co-stimulation blockade induced regulatory T cells demonstrate dominant and specific tolerance to porcine islet xenografts. Transplantation 2016 Sep 21. [Epub ahead of print]

Penno MA, Thomson RL, Couper JJ, ENDIA Study Group. Bunbury to Bundaberg, Darwin to Dover: establishing a successful Regional Participation Program for the ENDIA type 1 diabetes cohort study. Med J Aust. 2016 Nov 21;205(10):486

Petrie JR, Chaturvedi N, Ford I, Hramiak I, Hughes AD, Jenkins AJ, Klein B, Klein R, Ooi TC, Rossing P, Sattar N, Stehouwer CD, Colhoun HM. Metformin in adults with type 1 diabetes: design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): an international multicentre trial. Diabetes Obes Metab. 2016 Dec 9. doi: 10.1111/dom.12840. [Epub ahead of print]

Phillips JE, Couper JJ, Penno MAS, Harrison LC, ENDIA Study Group. Type 1 diabetes: a disease of developmental origins, Pediatr Diabetes 2016. DOI:10.1111/pedi.12425

Shetty, B, Fournier, P.A., Davey, R.J., Retterath, A.J., Paramalingam, N., Roby, H., Cooper, M., Davis, E.A., Jones, T.W. 2016, ‘Effect of Exercise Intensity on Glucose Requirements to Maintain Euglycemia During Exercise in Type 1 Diabetes’, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101, 3, pp. 972-980

Cho YH, Craig ME, Davis EA, Cotterill AM, Couper JJ, Cameron FJ, Benitez-Aguirre PZ, Dalton RN, Dunger DB, Jones TW, Donaghue KC. Cardiac Autonomic Dysfunction Is Associated With High-Risk Albumin-to-Creatinine Ratio in Young Adolescents With Type 1 Diabetes in AdDIT (Adolescent Type 1 Diabetes Cardio-Renal Interventional Trial). Diabetes Care 2015

de Bock MI, Roy A, Cooper MN, Dart JA, Berthold CL, Retterath AJ, Freeman KE, Grosman B, Kurtz N, Kaufman F, Jones TW, Davis EA. Feasibility of Outpatient 24-Hour Closed-Loop Insulin Delivery. 2015. Diabetes Care 38:e186-7

Farr RJ., Januszewski AS., Joglekar MV., Liang H., McAulley AK., Hewitt AW., Thomas HE., Loudovaris T., Kay TWH., Jenkins AJJ., Hardikar AA. A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy. Scientific Reports. 2015

Helen Phelan, Kim Donaghue, Fergus Cameron, Helen Clapin, Andrew Cotterill, Jenny Couper, Maria Craig, Elizabeth Davis, Craig Jefferies, Elaine Tham, and Timothy Jones. The Australasian diabetes data network (ADDN): first steps towards a national database resource. 2015. International Journal of Paediatric Endocrinology (Suppl 1): O35

Kwok-Leung Ong, Andrzej S. Januszewski, Rachel O’Connell, Alicia J. Jenkins, Aimin Xu, David R. Sullivan, Philip J. Barter, Wei-Ting Hung, Russell S. Scott, Marja-Riitta Taskinen, Anthony C. Keech, Kerry-Anne Rye. The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes Study. Diabetologia. 2015;58(3):464-73.

Lindblom R, Higgins G, Coughlan M, de Haan JB. Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy. 2015 Spring-Summer;12(1-2):134-56. doi: 10.1900/RDS.2015.12.134. Epub 2015 Aug 10. Rev Diabet Studies.

Mervyn Kyi, John M Wentworth, Alison J Nankervis, Spiros Fourlanos and Peter G Colman. Recent advances in type 1 diabetes, Med J Aust 2015; 203(7)

Pathiraja V1, Kuehlich JP1, Campbell PD1, Krishnamurthy B2, Loudovaris T1, Coates PT3, Brodnicki TC2, O’Connell PJ4, Kedzierska K5, Rodda C6, Bergman P7, Hill E7, Purcell AW8, Dudek NL8, Thomas HE2, Kay TW2, Mannering SI9. Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. 2015. Diabetes. 64:172-82 m

Trivedi P1,2, Graham KL1,2, Krishnamurthy B1,2, Fynch S1, Slattery RM3, Kay TW1,2, Thomas HE1,2. Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes. 2015. Immunol Cell Biol. doi: 10.1038/icb.2015.89.

Wilson Wong, Ryan J. Farr, Mugdha V. Joglekar, Andrzej S. Januszewski, Anandwardhan A. Hardikar. Probe-based real-time PCR approaches for quantitative measurement of microRNAs. Journal of Visualized Experiments. 2015;98

Zhao Y1, Scott NA1,2, Quah HS1,2, Krishnamurthy B1, Bond F1, Loudovaris T1, Mannering SI1,2, Kay TW1,2, Thomas HE1,2. Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate. 2015. Eur J Immunol 45:2494-503

Alicia J. Jenkins, Richard L Klein, Andrzej S. Januszewski, “Lipoprotein Glycation in Diabetes Mellitus” in “Lipoproteins in Diabetes Mellitus”, Alicia J. Jenkins, Timothy J. Lyons, Peter P. Toth (ed), Springer Science + Business Media Inc, New York, NY 2014 (DOI 10.1007/978-1-4614-7554-5_8)

Andrzej S. Januszewski, Nick Mason, Connie S. Karschimkus, Kevin G. Rowley, James D. Best, David N. O’Neal, Alicia J. Jenkins – Plasma SSAO activity in Type 1 diabetes is related to vascular and renal function but not to glycaemia. Diab. Res. Clin. Pract. 2014, 11(4):262-269

Andrew Pipingas, Andrew Sinclair, Kevin D Croft, Andrzej S Januszewski, Alicia J Jenkins, Trevor A Mori, Robyn Cockerell, Natalie A Grima, Con Stough, Andrew Scholey, Stephen P Myers, Avni Sali, Matthew Paul Pase. Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomized controlled trial. Journal of Functional Foods (IF 4.5) 2014

Benitez-Aguirre PZ, Craig ME, Cass HG, Sugden CJ, Jenkins AJ, Wang JJ, Cusumano J, Hodgson LAB, Lee K, Wong TY, Donaghue KC. Gender Differences in Retinal Microvasculature Through Puberty In Type 1 Diabetes: Are Girls at Greater Risk of Diabetic Microvascular Complications? . Investigative Ophthalmoloy & Visual Science 2014

Elleri D, Allen JM, Tauschmann M, El-Khairi R, Benitez-Aguirre PZ, Acerini CL, Dunger DB, Hovorka R. Feasibility of overnight closed-loop therapy in young children with type 1 diabetes aged 3-6 years: comparison between diluted and standard insulin strength. BMJ Diabetes Research and Care 2014

Ho M, Benitez-Aguirre PZ, Donaghue KC, Mitchell P, Baur LA, Jenkins AJ, Craig ME, Cowell CT, Garnett SP. Arterial elasticity in obese adolescents with clinical features of insulin resistance. Diabetes& Vascular Disease Research 2014

Ho M, Gow M, Baur LA, Benitez-Aguirre PZ, Tam CS, Donaghue KC, Craig ME, Cowell CT, Garnett SP. Effect of fat loss on arterial elasticity in obese adolescents with clinical insulin resistance: RESIST study. JCEM 2014

Marcovecchio, M.L., Woodside, J., Jones, T.W., Daneman, D., Neil, A., Prevost, T., Dalton, R.N., Deanfield, J., Dunger, D.B. 2014, ‘Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): Urinary screening and baseline biochemical and cardiovascular assessments’, Diabetes Care, 37, 3, pp. 805-813

Peter J. Little, Alan Chait, Andrzej Januszewski, Alex Bobik, David O’Neal, Alicia Jenkins, “Emerging lipoprotein-related therapeutics” in “Lipoproteins in Diabetes Mellitus”, Alicia J. Jenkins, Timothy J. Lyons, Peter P. Toth (ed), Springer Science + Business Media Inc, New York, NY 2014 (DOI 10.1007/978-1-4614-7554-5_23)