INTIMET: Insulin Resistance in Type 1 Diabetes Managed with Metformin

Harmful patterns of insulin resistance in the muscle and liver may be an explanation for increased cardiovascular disease in T1D.

The INTIMET study is a detailed investigation of insulin resistance in T1D and will test if metformin can improve insulin action in muscle and the liver. Participants will be asked to take metformin (or placebo tablets) and are required to attend 4 appointments over 6 months at the Garvan Institute in Sydney.

This study is also recruiting people aged 20-50 without type 1 diabetes, who will attend 2 study visits but not receive medication.

ANZCTR listing: ANZCTR12619001440112